In the evolving landscape of peptide science, buy cjc-1295 no-dac stands as a distinguished research compound, prized for its unique pharmacokinetic profile. Supplied in a lyophilized form of 10mg, this analog of the parent CJC-1295 is specifically engineered without the DAC (Drug Affinity Complex) technology. This modification fundamentally alters its duration of action, bioavailability, and interaction with biological targets, making it a subject of significant interest for laboratory studies focused on growth hormone (GH) physiology, tissue repair, and metabolic regulation.
This product description provides a detailed technical overview of buy cjc-1295 no-dac 10mg, including its mechanism of action, key differences from its DAC counterpart, proposed research applications, storage protocols, and safety considerations. This material is strictly intended for in-vitro research and laboratory use only. It is not for human consumption, therapeutic use, or veterinary application outside of approved controlled studies.
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH), specifically a modified version of GHRH(1-29)—the biologically active fragment of endogenous GHRH. The parent compound was designed to have an extended half-life due to the inclusion of a Drug Affinity Complex (DAC), which allows it to bind covalently to serum albumin.
buy cjc-1295 no-dac , conversely, omits this DAC moiety. As a result, it is also frequently referred to as Modified GRF (1-29) or Tetrasubstituted GRF. Despite the removal of the DAC, it still retains four amino acid substitutions (specifically at positions 2, 8, 15, and 27) that confer resistance to enzymatic degradation by dipeptidyl aminopeptidase IV (DPP-IV). This means that while it does not have the prolonged albumin-binding half-life of the DAC version, it still has a significantly longer functional window than unmodified GHRH (which degrades within minutes).
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: Approximately 3367.9 g/mol
Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
Purity: ≥98% (determined by HPLC and mass spectrometry)
Physical Form: White lyophilized powder
Pack Size: 10mg per vial
Understanding the biological activity of buy cjc-1295 no-dac requires a basic grasp of the Growth Hormone Releasing Hormone (GHRH) axis. Endogenous GHRH is released from the hypothalamus and binds to GHRH receptors on the somatotroph cells of the anterior pituitary. This binding triggers a cascade that leads to the synthesis and pulsatile release of growth hormone (GH) into systemic circulation. GH then stimulates the liver and other tissues to produce Insulin-like Growth Factor 1 (IGF-1), which mediates many of the anabolic and metabolic effects associated with GH.
CJC-1295 (NO DAC) functions as a potent, long-acting GHRH agonist. Its four amino acid substitutions protect it from rapid DPP-IV degradation, giving it an effective research half-life of approximately 30–60 minutes—compared to just 5–10 minutes for unmodified GRF(1-29). However, unlike CJC-1295 with DAC, which can create sustained, non-physiological GH elevation for days, the NO DAC version is designed to amplify the natural pulsatile release of GH.
This is a critical distinction. Physiological GH secretion is pulsatile, not constant. Prolonged, flat elevations of GH (as seen with DAC) can potentially lead to receptor desensitization or negative feedback inhibition. The NO DAC variant is hypothesized to work in harmony with the body’s natural rhythms, increasing the amplitude of each endogenous GH pulse without disrupting the frequency or creating a continuous, unphysiological state.
Choosing between these two analogs depends entirely on the research model. The table below highlights the essential distinctions:
| Feature | CJC-1295 (with DAC) | CJC-1295 (NO DAC) |
|---|---|---|
| DAC Present | Yes – binds to albumin | No – no albumin binding |
| Half-Life | 5–8 days (very long) | ~30 minutes |
| GH Release Pattern | Sustained, non-pulsatile elevation | Amplified natural pulses |
| Desensitization Risk | Higher potential due to continuous exposure | Lower – mimics physiological rhythm |
| Typical Research Focus | Chronic GH deficiency models, sustained IGF-1 elevation | Pulsatile GH dynamics, recovery models, acute anabolic signaling |
| Dosing Frequency (in vitro/in vivo models) | Once every 5–7 days | Typically multiple times per day |
For researchers modeling the body’s natural GH axis or studying protocols that avoid receptor downregulation, CJC-1295 (NO DAC) is often the preferred tool.
The 10mg format of buy cjc-1295 no-dac is suitable for a range of laboratory investigations. While human clinical data is limited, animal and cellular studies have explored the following areas:
This compound is ideal for studying how increased GH pulse amplitude affects downstream signaling pathways, including JAK2-STAT5, MAPK, and PI3K/Akt. Researchers can investigate how the timing and magnitude of GH release influence gene expression in the liver, bone, and adipose tissue.
Because GH and IGF-1 play pivotal roles in wound healing, collagen synthesis, and muscle protein synthesis, CJC-1295 (NO DAC) is used in models of soft tissue injury, fracture healing, and even neural recovery. Its pulsatile action may offer advantages over continuous GH administration by preventing receptor fatigue in chronic repair studies.
GH is a potent lipolytic hormone. This peptide has been examined in rodent and cell culture models to assess its impact on fat oxidation, lipid profiles, and glucose homeostasis. The NO DAC version allows researchers to study metabolic effects without the confounding factor of constant GH elevation, which can induce insulin resistance in some models.
Endogenous GH release is tightly coupled to slow-wave (deep) sleep. CJC-1295 (NO DAC) can be used in chronobiological research to explore how exogenous GHRH analogs interact with the hypothalamic-pituitary axis during different phases of the sleep-wake cycle.
In certain invertebrate and murine models, modulating the GH/IGF-1 axis has been linked to lifespan extension. CJC-1295 (NO DAC) offers a controlled way to temporarily elevate GH pulses to study trade-offs between anabolic function and aging biomarkers.
Proper handling is essential to preserve peptide integrity.
Reconstitution: For a 10mg vial, add 1mL to 2mL of sterile bacteriostatic water (0.9% benzyl alcohol) or sterile acetic acid (0.1%) depending on your protocol. Inject the diluent slowly down the inner wall of the vial; do not shake. Swirl gently until the solution is clear.
Storage: Lyophilized powder should be stored at -20°C (freezer), away from light and moisture. Once reconstituted, aliquot to avoid repeated freeze-thaw cycles and store at 4°C for short-term use (up to 2-3 weeks) or -20°C for longer storage.
Concentration Calculation: 10mg = 10,000mcg. If reconstituted with 2mL, each 0.1mL (10 units on a 1mL insulin syringe) contains 500mcg of peptide.
This CJC-1295 (NO DAC) 10mg is manufactured under strict quality control standards:
HPLC Purity: ≥98% – Verified by independent analysis.
Mass Spectrometry: Confirmed molecular weight.
Endotoxin Level: <1.0 EU/mg.
Sterility: Filter-sterilized and lyophilized in a sterile environment.
IMPORTANT SAFETY NOTICE: This product is supplied FOR LABORATORY RESEARCH USE ONLY. It is not a drug, medicine, or dietary supplement. It has not been approved by the FDA, EMA, or any other regulatory agency for human or veterinary use. Do not administer to humans or animals. Use only by qualified researchers in appropriate laboratory facilities with adequate safety equipment (gloves, goggles, fume hood).
Potential side effects reported in animal studies (at supra-physiological doses) include transient injection site reactions, mild water retention, and fluctuations in blood glucose. Researchers should consult Material Safety Data Sheet (MSDS) before use.
The 10mg vial provides an economical and practical quantity for medium-scale research. It offers enough material for multiple dosing regimens in rodent models (e.g., 20-30 mice for a 2-week study at 100mcg/kg/day) or for extensive cell culture work. The size balances cost-effectiveness against the risk of degradation from opening a vial too many times—researchers can reconstitute only what is needed and store the remainder dry.
buy cjc-1295 no-dac 10mg is a sophisticated research peptide that offers a nuanced approach to studying growth hormone physiology. By amplifying natural GH pulses rather than creating a flat, sustained elevation, it provides a more physiological model for investigating tissue repair, metabolism, and endocrine dynamics. Its resistance to DPP-IV degradation ensures a reliable window of activity, while the absence of the DAC moiety avoids the potential pitfalls of continuous receptor activation.
Mon – Fri : 8:30 – 18:00
chroma peptides © 2026 Created
Reviews
There are no reviews yet.